Abstracto

A physical approach to AD Pathogenesis and treatment

Caterina Guiot, Eleonora Ficiarà, Shoeb Ansari, Silvia Boschi, Federico D’Agata

The biological mechanisms responsible for clinical Alzheimer’s disease (AD) are very elusive and many hypotheses so far proposed (based on accumulation of tau protein and amyloid beta protein) are not conclusive or at least are not able to early predict the disease progression. The etiology of AD involves many factors with complex cause-effect relationships. Among them, the role played by possible alterations in brain iron metabolism is becoming very attractive 1]. In fact, many evidences suggest that imbalance of iron metabolism is involved in neurodegenerative disorders, leading to overload phenomena in several brain regions and dysfunction of iron-related proteins 2].