Abstracto

Two novel Cd (II) and Cu (II) complexes based on 3, 5-bi (4-carboxyphenoxy)-benzoic acid: anti-inflammatory activity in sympathetic ophthalmia

Li Sun, Li-Yan Sha, Jing Jiang

The reactions of a semirigid tripodal carboxylic ligand 3, 5-bi (4-Carboxyphenoxy)-Benzoic Acid (H₃BCPBA) with Cd (NO₃)2 and CuCl₂ • 2H₂O afford two novel coordination polymers, ((Cd₃(BCPBA)₂) (DMA))_n (1) and [Cu₂(HBCPBA)₂(DMA)₃]_n (2) (DMA=N, N-dimethylacetamide), in which 1 shows a three-dimensional (3D) structure with a 5, 6, 6-connected net structure and 2 features a non-interpenetrating 3D networks with 1D small-size channels running along the a axis. In addition, anti-inflammatory properties of the synthesized compounds were evaluated in vivo utilizing a standard acute carrageenan-induced paw oedema method in rats.