Abstracto

Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection

Reza Ranjbar, Atabak Mohammadi

Introduction: Helicobacter pylori is a Gram-negative, moving, helix–shaped and Microaerophilic bacterium which infects the human’s stomach in childhood and stays for a long time. Helicobacter pylori is a gastrointestinal pathogen in human body and causes chronic and active stomach inflammation as well as gastrointestinal ulcers. The purpose of this study is to investigate the effects of curcumin on Helicobacter pylori in the mice model.

Material and Methods: In this study, after induction of Helicobacter pylori disease to the Balb/c mice, we started to treat different groups of mice in the second week of sicknesses using oral administration of curcumin, common antibiotics in curing Helicobacter pylori, and antibiotics with curcumin. One group received no treatment as a negative control group and the other group received Helicobacter pylori without any treatment as a positive control group. Oral prescriptions were conducted within 15 days and blood sampling was then carried out from the mice hearts. The rate of anti-Helicobacter pylori antibodies was then calculated in serum and then, urea tests were done on the mice stomach.

Results: Results revealed that the effectiveness of Curcumin in rate is less than the antibiotic group but decreased the amount of Helicobacter pylori infection compared to the infected host group. Combined therapy had synergistic effects and caused a more significant reduction in gastrin, IFN-γ, MPO activity and lipid peroxidation compared to mice receiving each monotherapy.

Conclusion: It seems that Curcumin, as a natural complex without any side effects, will receive enough attention in inhibiting the infection proliferation.