Abstracto

Spectrophotometric determination of ziprasidonehydrochloride (zpn), 5-[2-(4-benzo [d] isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1, 3-dihydindol-2-one hydrochloride using gold (III).

A Mohamed Sikkander*, Rafi SK

Ziprasidone hydrochloride (ZPN) forms a pink-coloured complex among gold (III) in an aqueous solution at pH 5.0. The ZPN complex show the absorption utmost at 600 nm and the BeerLambert’s law is obeyed in the range of 5.0-60.0 μg/ml. The pragmatic formula and molecular mass of Ziprasidone hydrochloride (ZPN), 5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3- dihydro-indol-2-one hydrochlorideare C21H22Cl2N4OS and 448.94 correspondingly. In the present work, it was in employment for the receptive spectrophotometric determination of ZPN. The molar absorptivity and sandal’s sensitivity were found to be 7.48 × 103 mol-1 cm-1 and 0.0604 μg/cm2 correspondingly. The complex shows 1:1 [ZPN: Au (III)] stoichiometry with a steadiness constant of 2.54 × 104. The effect of interference of various amounts of excipients has been studied. In addition to zero- order, first derivative spectrophotometric technique was also developed for the determination of ZPN in trace amount which was more responsive than the zero-order method. The results were in exceptional agreement with certified values. The developed method is very competent for the determination of ZPN in various kinds of pharmaceutical formulations.