Abstracto

Role of genomic instability in cancer

Mandy Mahoney

Genomic instability is an attribute of maximum cancer cells. It is an enlarged tendency of genome alteration through cell division. Cancer often results from injury to numerous genes adjusting cell division and tumor suppressors. It is identified that genomic integrity is closely observed by several surveillance devices, DNA injury checkpoint, DNA healing technology and mitotic checkpoint. A flaw in the regulation of any of these mechanisms often results in genomic instability, which predisposes the cell to malignant alteration. Posttranslational changes of the histone tails are carefully associated with the regulation of the cell cycle as well as chromatin structure. DNA methylation status is also associated to genomic integrity