Abstracto

Outcome of trabeculectomy with intraoperative subtenon injection of mitomycin C

Pir Salim Mahar, Asma Rahman

Purpose: To evaluate the efficacy of trabeculectomy with intraoperative subtenon injection of
Mitomycin C (MMC) in terms of control of Intraocular pressure post-operatively. Study design: Retrospective, observational
Methods:Atotal of 49 patients medical records who underwent trabeculectomy with intraoperative subtenon injection of MMC with diagnosis of primary open angle glaucoma (POAG) from January 2017 to December 2018 were evaluated to see the post-operative outcomes in terms of control of intraocular pressure (IOP) with 12 months follow-up. The medical records were retrieved using the hospital information system. Age, gender, pre-operative IOP, best-corrected visual acuity (BCVA), co-morbids, previous surgery, central corneal thickness (CCT), fundus findings, number of glaucoma medications and postoperative complications were obtained by using a proforma.
Results: Total 72 eyes of 49 patient records were evaluated to see post operative outcomes at three, six and twelve months follow up. The mean IOP preoperatively was 24.68±13.66 mm Hg with maximum anti-glaucoma treatment. After the surgery at 3 months follow-up, the mean IOP was 13.69±6.68 mmHg, which was slightly changed at six and twelve months as 12.68±4.04 and 13.33±4.8 mmHg respectively (P-value 0.001). Preoperatively mean CCT was 529.81±28.75 and at 12 months follow-up after surgery was 530.45±29.43 with P-value 0.245. BCVA outcomes were seen at each follow-up and results were found to be statistically significant (P value ≤ 0.05).
Conclusions: Twelve months follow-up of trabeculectomy show that intraoperative subtenon injection of MMC is effective in terms of control of IOP postoperatively with minimal complications in patients with POAG.