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Neuroendocrine cell hyperplasia in ulcerative colitis and lymphocytic colitis.

Arevalo Fernando, Zurita Fiorella, Vergara Greys, Ramirez Rocio, Castillo Joseph, Monge Eduardo

Some authors have found increase of neuroendocrine cells in microscopic colitis and ulcerative colitis. The aim of this study is to evaluate the presence of neuroendocrine cells in ulcerative colitis, lymphocytic colitis and collagenous colitis. Immunohistochemistry was performed to identify neuroendocrine cells through marker chromogranin A (CgA). The study included 10 cases of Lymphocytic colitis, 10 cases of collagenous colitis, 10 cases of ulcerative colitis and 10 controls. There was statistically significant difference in the count of neuroendocrine cells, between lymphocytic colitis and control (p=0.019104), and between ulcerative colitis and controls (p=0.0077). In Collagenous colitis there was an increase in neuroendocrine cells but we failed to find statistical differences. In conclusion similar to reported by other authors, we could observe neuroendocrine cell hyperplasia in lymphocytic colitis and ulcerative colitis compared with controls.