Abstracto

Intendments and chemoprevention of cancer and role of preventive vaccines

Jennifer Ben

Years of unsuccessful attempts to target established tumors with vaccines have meant that patient survival is only possible when used in a prophylactic context, as traditional infectious disease vaccines usually do. While true primary cancer prevention is only a long-term goal, secondary and tertiary prevention are yielding promising clinical results. The combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors holds further promise for future cancer control successes, but prevention requires a significant reduction in currently reported toxicities. These considerations, together with our improved understanding of tumor antigens, leave room for optimism about the future.