Abstracto

Impact on certain essential trace elements in polycystic ovarian syndrome patients in north-west Indians

Kuldip Singh

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that affects 6%-7% of premenopausal women. Ferritin is a ubiquitous intracellular protein that is essential for the regulation of iron homeostasis. Iron is a strong pro-oxidant and high body iron levels are associated with an increased level of oxidative stress, pathogenesis of various disease like Diabetes, Cardiovascular diseases, PCOS etc.

Aim: The present study was designed to evaluate certain essential trace elements like Ferritin, Copper, Magnesium, Zinc, Selenium levels in young PCOS women’s from tertiary care hospitals of Punjab state of India.

Research Design and Methods: 35 PCOS patients were recruited from the urban and rural area of the Punjab State in the age range of 20 to 40 years.

Results: Serum ferritin (P ≤ 0.001) and copper (P ≤ 0.05) concentrations were significantly increased while a significant fall in zinc (P ≤ 0.05), magnesium (P ≤ 0.05) and selenium (P ≤ 0.01) was observed in women presenting with PCOS with respect to healthy control subjects.

Conclusion: A significant increase in ferritin and Cu while a significant fall in Se, Zn and Mg levels observed in the present study suggesting that these essential trance elements are an important etiological role in the pathogenicity and increased complication of PCOS.