Abstracto

Human amniotic allograft tissue matrix with platelet rich plasma injections and prolotherapy to treat chronic knee pain and severe osteoarthritis

Jeffrey Xue, Yibing Li, Aswathy Krishna Kumar, Leah Tabor, Christina Luncsford

Osteoarthritis (OA) originates from ligament laxity, tendinopathy, cartilage degeneration, and previous joint injuries and can result in functional limitations and chronic pain. Treatment include a mixture of human amniotic allograft tissue and plasma rich plasma (PRP) alongside dextrose prolotherapy. The human amniotic allograft tissue is extracted from a healthy, living donor and contains protein collagens, growth factors, and receptor antagonists. PRP contains additional growth factors, and dextrose prolotherapy is used to stimulate the body for regeneration of the tissue. This study is to assess the clinical outcome of the human amniotic tissue and PRP alongside prolotherapy on the pain and function of the patients.