Abstracto

Glyphosate exposure exacerbate gluconeogenic enzymes in adult male Wistar rats

Aashiq Mohamed P, Gayathri R*, V Vishnu Priya, J Selvaraj, Kavitha S

Glyphosate is an herbicide. It is applied to the leaves of plants to slaughter both broadleaf plants and grasses. Glyphosate being water soluble enters the food chain by biomagnification. Increased concentration of glyphosate may lead to oxidative stress and thus can induce insulin resistance associated with diabetes mellitus. Oxidative stress is invaded in the dysregulation and increased gene expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, a key gluconeogenic enzyme.