Abstracto

Expression of NF-kappaB and p38 under intervention of rutin in lung cancer therapy

Xiao-hua Li, Zhi-yi Liu, Yue Gu, Zhe Lv, Yan Chen, Hai-cheng Gao

Purpose: Rutin has been widely used in clinic for treatment of cardiovascular diseases in China. But rutin was rarely used in prevention and treatment of cancer. This study investigated the expression of NF-κB and p38 under intervention of rutin in lung cancer.

Methods: In this experiment, cells were divided into control group, cisplatin group, and rutin groups (low, middle and high). The MTT, flow cytometry, Western blot and immunofluorescence staining methods were used to examine cell cycle and the expression of NF-κB and P38, respectively.

Results: Rutin could regulate the cell cycle. In addition, rutin reduced the expression of NF-κB and P38.

Conclusion: These novel findings indicate that rutin inhibits NF-κB and P38 activity and regulates the development of lung cancer.