Abstracto

Efficacy observation of radiotherapeutic plans developed according to prognostic factors of brain metastases

Tangbing Wu, Dejun Qian, Xiaoyi Sun, Huiming Bai, Jing Wang

This study aimed to assess the efficacies of different radiotherapeutic plans for brain metastases (BM). A total of 110 patients with BM treated from January 2008 to December 2012 were retrospectively included, and divided into the standard group (n=57) and the auxo-dose group (n=53) according to their Karnofsky scores (KPS) and extracranial lesions. The standard group underwent whole brain radiotherapy with 30 Gy in 10 doses over 2 weeks, while the auxo-dose group received an increased local boost dose compared to the standard group, according to the number and invasiveness of the metastases. The follow-up lasted 2 years to observe the effect of local auxo-dosage on the prognosis of BM. The median survival time (17 months vs. 5 months), 1-year survival rate (69.8% vs. 33.3%), and 2-year survival rate (41.5% vs. 0) of the auxo-dose group were higher than those of the standard group. The 1- year complete remission (42.5% vs. 13.3%) and 1-year partial remission (48.8% vs. 6.7%) rates of BM in the auxo-dose group were higher than that in the standard group; 48 patients of the auxo-dose group died, with the main cause being extracranial tumor (60.4%, 29/48). All patients of the standard group died during the observation period, with the main cause as intracranial tumor (42.1%, 24/57). All of the above comparisons were significant (P<0.05). Compared with standardized whole-brain radiation therapy, radiotherapy with an additional local dose improved remission rates while reducing the longterm mortality of BM.