Revista de toxicología clínica y experimental


Design and Fabrication of Ocular Drug Delivery System (ODDS): Nanoparticles an advance role in Anterior Segment Delivery ASD

Deepesh Lall

Ocular drug delivery still a challenging practice an attempt made to overcome the conventional dosage form with improving the Bioavailability and Concerning Therapeutic desired rate of Anterior Segment Delivery. Drug Delivery to the eye still a challenging practice to overcome Nanoparticles incorporating for optimal Therapeutic activity, as drug molecules treated with the nanoparticles which help to cross from ocular barriers without causing permanent tissue damage. At present availability for the Ocular Anterior segment delivery the conventional dosage forms available with their limitations Bioavailability rate  for example solutions, suspensions and some ointments, while novel dosage forms playing important role for achieving more percentage of Bioavailability and rate of absorption without causing optical irritation, for example liposomes, nanoparticles, and implants. Aim of this work also come under the conclusion  80% to 90% of the available  formulations present in the market are conventional dosage forms, and they have limited bioavailability due to precorneal clearance and very short duration of action while novel drug delivery system  Nanoparticles possess advanced drug delivery medium. On study of certain literature review study conclusion found that major researcher is going with the development of sustained release and control release systems with higher precorneal Bioavailability. Such systems can improve the ocular bioavailability of drugs and provide high patient compliance. With going through several literature review study found   therapy into an eyes either by solutions, ointments dropping deteriorating by age, but nanoparticles like micelle, liposomes, Nano sponge’s and dendrimers hydrogel concluded efficient medium for chitosan, hyaluronic acids and antiglaucoma and these novel formulation have ability to deliver drugs in sustain and control release of medicaments. objective of this review is by using nanoparticles overcome the barriers of  Ocular Anterior segment delivery with increase and optimistic Bioavailability with crossing Ocular barriers