Abstracto

Association between interleukin-4 genetic polymorphisms and the risk of cerebral infarction in a population of China

Hu Wei, Gao Feng, Wang Pei, Wang Gang, Zhang Yuelin

We conducted a case-control study to evaluate the correlation of IL-4 rs2243250 and rs2070874 polymorphisms with the risk of cerebral infarction, and the gene-environmental interaction between IL-4 and environmental factors. A total of 344 patients with cerebral infarction and 360 healthy controls were enrolled in this case-control study. The genotyping of the IL-4 rs2243250 and rs2070874 was performed by Polymerase Chain Reaction (PCR) amplification and single base extension assays in a 384- well plate format on the sequenom MassARRAY platform. By logistic regression analysis, males (OR=1.44, 95% CI=1.07-2.02), creatinine ≥ 1.00 (OR=1.74, 95% CI=1.28-2.38), a history of hypertension (OR=1.64, 95% CI=1.18-2.30) and diabetes mellitus (OR=1.76, 95% CI=1.14-2.73), and high level of HDL-c (OR=2.95, 95% CI=1.46-5.97) were associated with an increased risk of cerebral infarction when compared with the reference group. We observed that the TT (OR=3.32, 95% CI=1.81-6.06) and CT+TT (OR=1.51, 95% CI=1.11-2.06) genotypes of rs2243250 were correlated with a higher risk of cerebral infarction in comparison with the CC genotype. The rs2243250 had interaction with gender and HDL-c in the risk of cerebral infarction. In conclusion, our study suggests that rs2243250 may be considered as a useful biomarker for prediction of the susceptibility of cerebral infarction.