Abstracto

Analysis of the influences of supplementing qi and nourishing yin formula on HR, ASP, ADP, LVSP, LVEDP and ET-1 of heart failure rats

Luan Yingni

Objective: To explore influences of supplementing qi and nourishing yin formula on death rate, cardiac function, haemodynamics and ET-1 of heart failure rats.

Methods: This study used ADR to establish heart failure model, they were divided into model control group, Shexiang Baoxin pill positive control group, high dose, medium dose and low dose experimental group of supplementing qi and nourishing yin formula, blank healthy control group. There were 12 rats in each group, half male and half female. They were given intragastric administration twice one day for 6 w continuously. Then we observed death conditions of rats, measured cardiac function of rats, including HR, ASP, ADP, LVSP, LVEDP and ET-1 level in serum.

Results: After administration of the last time, average weight and HR of rats in different doses of supplementing qi and nourishing yin formula lower than the healthy control group, but LVEDP higher than the healthy control group, P<0.05. ASP, ADP, LVSP, ET-1 level in serum of rats in high dose group were in accordance with healthy control group, P>0.05; but average weight, HR, ASP, LVSP, LVEDP and ET-1 level in serum all higher than model control group and positive control animal, P<0.05. Average weight, various parameter of haemodynamics and ET-1 level in serum in medium and low dose group were in accordance with positive control group, P>0.05; but it higher than model control group, P<0.05.

Conclusion: Supplementing qi and nourishing yin formula can enhance myocardial function of HF rats, improve abnormal haemodynamics, lower ET level in serum, which has good clinical application prospect.