Abstracto

A study on myocardial performance index in children with nephrotic syndrome in age group 1-12 years.

Tharanidharan SP*, RK Singh, Manjusha Goel, Jyotsna Shrivastava

Background: Nephrotic syndrome (NS) is a common paediatric kidney disease characterised by leakage of protein from the blood into the urine through damaged glomeruli. An increased risk of cardiovascular disease exists in patients with NS because of hyperlipidemia, increased thrombogenesis, and endothelial dysfunction. Objective: Study of Myocardial Performance Index in children with Nephrotic Syndrome and its correlation with age of onset, relapses, hypertension and lipid profile Methods: Total 70 children with nephrotic syndrome of age group 1-12 years included in this observational study. All Children subjected to full history taking, clinical examination and lab studies including serum albumin, serum cholesterol, renal function test. Myocardial performance Index of these children calculated by Doppler Echocardiography using Tissue Doppler Imaging performed in the apical four chamber view. Isovolumetric Contraction time (IVCT), Isovolumic Relaxation time (IVRT), Ejection Time (ET) and MPI were calculated. Results: In our study the mean myocardial performance index is found to be .398±0.045. Significant increase in the Mean Myocardial Performance Index of the patients with the increase in the number of relapse and duration of disease was observed. Myocardial Performance Index has inverse relation with Global ventricular function. Increase in MPI indicate worsening Global Ventricular Function. MPI is significantly higher in patients of Nephrotic Syndrome who had hypertension as compared to patients with normal blood pressure. There is a significant positive correlation between Serum Cholesterol and MPI.